Lifeblood Research Lab
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Lifeblood Research Lab The beginning of new era for beautiful skin with blood flow science

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Holistic care that uses
your body’s natural
blood flow

Skin is constantly threatened by a variety of factors, including dehydration, UV rays, stress and aging. Yet instead of learning more about how to maintain beautiful skin, we have relied on temporary solutions that target each of the factors individually. Gleaned from over 120 years of skin research, SHISEIDO has uncovered the answer by focusing on a mechanism inherent to us all, circulation within the skin.
And the key to this is blood vessels and blood flow.
By improving blood vessels and thereby blood flow, which delivers important nutrients and immune cells throughout the body, it’s possible to realize beautiful skin that glows from within. Introducing Lifeblood Research™, a new beauty science that takes advantage of the life force in each of us. Lifeblood Research™ transcends all current skincare approaches.

Not only exercise and diet.
This is the enhancement of  
blood flow based on  
groundbreaking research. 

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There are times when we feel great about our skin, such as in the morning after a good night’s sleep, after a refreshing run or yoga session, or right after a warm shower. The common thread between these instances is increased blood flow, and it’s this improved circulation that leads to more beautiful and healthy. Unfortunately, the enhanced circulation obtained through heat or massage is only temporary.

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This is why SHISEIDO began researching blood vessels and blood flow to develop cutting-edge beauty science technology. We have scientifically proven that better blood flow improves the texture of skin, and also revealed that caring for blood vessels carrying immune cells is essential for healthy.

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Good blood flow is the foundation of beautiful skin.

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How do you get your skin  
into excellent condition,
and then get it
to stay that way?  
The answer may be
in your blood flow. 

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After a hot bath or a good night’s sleep, your skin’s condition is excellent, and it feels good. But it’s difficult to keep your skin like that.
SHISEIDO conducted a survey in four countries around the world that revealed new secrets to beautiful skin that women around the world have discovered while staying at home.
Note: Survey of a total of 2,933 women aged 20-49 living in
Japan, China, the United States and Italy

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Recently, people all over the world have undergone major lifestyle changes, including the daily use of masks, and the popularity of online conferencing. Bare skin is more visible than ever, and more people are placing importance on skin care to help keep their skin from drying out.
SHISEIDO’s survey results show that people want resilient and beautiful skin, and that they are more aware of the need for skincare to get their skin into its best condition.

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So, what is the ideal skin condition? When asked to imagine ideal skin, many women said “bare skin after a good night’s sleep” and “bare skin after a bath or shower.”

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More than 70% of people consider “improved blood flow” essential to elevating the condition of bare skin. This shows that many people feel that there is a connection between beautiful skin and blood flow.

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Blood flow carries oxygen to every corner of the skin, increasing hemoglobin and improving the complexion. The latest dermatological studies also prove that superior blood flow improves skin elasticity. So it turns out that that the awareness our survey participants expressed about “blood flow” as a factor in the skin’s beauty is scientifically valid.
Coming soon: detailed results of SHISEIDO’s many years of skin care research on how to maintain ideal skin conditions. PLUS, new tips discovered recently by survey respondents while staying home.

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Promoting blood flow
and boosting immunity:
Double Inner Defense with
Houttuynia Cordata Extract 

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What’s behind the loss of our ideal skin conditions? What happens to that clarity and elasticity we notice after a bath or a great night’s sleep? The answer has to do with the quality of our blood flow—which carries the all the nourishment for great skin conditions to every corner of the skin.
With aging and exposure to external factors, blood flow tends to stagnate, and immunity declines. As a result, skin conditions become less than ideal. This inspired SHISEIDO Lifeblood Research™, and its studies on how blood flow can be constantly promoted. From this work comes Shiseido’s new discovery, Double Inner Defense.

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Shiseido has found that when the skin’s immune functions receive a certain specific double inner defense boost, skin can maintain its own ideal conditions. Now, through the results of Lifeblood Research™, Shiseido has developed technology called Double Inner Defense, to give skin that double boost it needs to promote constant blood flow. Houttuynia Cordata Extract enlarges and extends capillaries and carries immune cells to every part of the face, and Fermented Hibiscus Extract activates immune cells known as NK cells.

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Our immune system protects us from bacteria and viruses, and maintains our skin’s health. Capillaries support this by carrying nutrients and oxygen to every corner of the body. In healthy young skin, these capillaries are well spaced, they reach all over the skin and they provide a boost that gives skin elasticity. In skin that has been worn down by aging and external factors, capillaries become fine, brittle, and irregularly spaced—sometimes even disappearing. This causes blood flow to stagnate.

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The extract of Houttuynia Cordata is being researched heavily around the world. This plant has a long history as a natural remedy in Asia. Shiseido has discovered that Houttuynia Cordata Extract enlarges and extends capillaries, causing the skin as a whole to become more elastic, and allowing immune cells to flow to every corner of the skin.Rreference:Sawane et al, Blood vessels sense dermal stiffness via a novel mechanotransducer, APJ, Angiogenesis(2021)

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By promoting constant blood flow to transport immune cells all over the skin, Houttuynia Cordata Extract can renew skin immunity, leading to glowing, life-filled skin.
Lifeblood Research has also illuminated mechanisms for activating immune cells called NK cells. Look for details on this soon!

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Promoting blood flow
and boosting immunity:
Double Inner Defense with
Fermented Hibiscus Extract 

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In this age of constant innovation, does skin still have to lose its elasticity and luster as it ages?
For years, SHISEIDO Lifeblood Research™ has been pursuing this question, and researching the path to ideal skin conditions.The key outcome from this research is a technology that promotes constant blood flow, which has led to the development of Double Inner Defense.
In a previous release, we introduced Houttuynia Cordata Extract—the defense mechanism that enlarges and extends capillaries and carries immune cells to every corner of the face. In this edition, we detail the other defense mechanism—Fermented Hibiscus Extract, which activates immune cells known as NK cells.

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Our immune system doesn’t just protect us from bacteria and viruses. It also maintains healthy skin. For this we can thank our NK cells, also known as natural killer cells. Transported throughout the body by the blood, NK cells are on patrol everywhere, removing contaminants, and senescent fibroblast cells which secrete elements that promote aging.
So, if NK cells remove those senescent cells, why does our skin keep losing glossiness and elasticity as we age? This mystery has remained unexplained—until recently.

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SHISEIDO engaged in collaborative research with the globally renowned CBRC (Cutaneous Biology Research Center), and the findings of this research clarify why NK cells weaken over time.
We now know that instead of dying, senescent cells actually grow in number in aging skin, and this provokes a “zombification” process that negatively affects other cells in the surrounding area. The study also confirmed that NK cell activity declines with age, and that adds to the problem by diminishing their ability to clear senescent cells out.
Based on these findings, SHISEIDO’s idea for maintaining ideal skin conditions is to prevent the “zombification” of senescent cells by increasing NK cell activity as we age.

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This idea led us to the Roselle flower, which is a type of Hibiscus. Used since ancient times in herbal teas, and consumed as a beauty supplement by Cleopatra, the Roselle is a sustainable plant that can be completely utilized, including the fibrous materials from its stem, and oil from its seeds.
SHISEIDO discovered that extract from this flower’s sepal (a modified leaf on the underside of a petal) and lactic acid bacteria have the effect of strengthening immune functions, and that Fermented Hibiscus Extract has the effect of activating NK cells.

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Double Inner Defense activates immune cells called NK cells. It also enlarges and extends capillaries, so immune cells are delivered via the blood to every corner of the face.
Houttuynia Cordata Extract and Fermented Hibiscus Extract activate two defensive mechanisms that are vital for beautiful skin. They also boost immunity, so we can keep our skin glossy and full of life.
Lifeblood Research™ will continue, forward into a future where healthy, vibrant skin can be maintained infinitely.

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Multi angle visualization
of blood vessels.
SHISEIDO’s technology is
for deliver
the secret
of beauty. 

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In blood flow research, precise measurement is essential. Until now, limits in conventional beauty science have made impossible the study of blood vessels that spread out in all directions beneath the skin. Now, thanks to proprietary SHISEIDO special imaging technology, OCT, the state of the capillaries can be captured in 3D by photographing the outside of the skin with a special camera.

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Then, by analyzing blood vessels in multi angle we can understand the effects of lifestyle on skin and thereby determine the future state of blood vessels.

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In September 2020, we succeeded in observing the capillaries of an entire face and in 3D no less, world leading. Previously, this had only been possible on individual parts of the face, one at a time. Thanks to this breakthrough, it becomes possible to accurately understand the characteristics of the blood vessels according to their individual parts regardless of age, ethnicities and gender, and to detect the partial modulations of blood vessels which are invisible if looking at the skin from the outside.

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Using these game-changing blood flow and circulation measurement technologies, we hope to extend conventional care to individual concerns, such as age spots and skin firmness. We are also developing a concept that covers comprehensive facial care, where we will be able to predict future skin conditions by observing the face’s blood vessels.

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SHISEIDO Skin Visualizer™
visualizes  
skin’s Beauty Circulation 

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You know how it goes. You’ve got something important on your calendar, and when the big day arrives, and your skin isn’t looking so good. You want your skin to be in good condition all the time so you can stop worrying about skin every day. But skin condition varies form person to person, so it’s not easy to hit on the ideal skincare for you. That’s why SHISEIDO has focused on “beauty circulation” –the definition of beautiful skin in SHISEIDO’s beauty theory is that the skin has three elements of radiance, smoothness and resilience, regardless of your age, gender, ethnicity or skin type.
To help you do that, SHISEIDO created the Skin Visualizer™. Now anyone can easily measure their beauty circulation.

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To measure beauty circulation, you need to see the balance between the three factors SHISEIDO believes are the indicators of beautiful skin: radiance, resilience and smoothness.
When there is a good level of beauty circulation, the skin is in good condition, which leads to Healthy Vibrant Skin. Although everyone’s skin has the ability to become more beautiful, that ability gradually declines with age and external stress. By visualizing the beauty circulation in the skin, each and every person can identify the ideal skincare for them, in order to revive their skin’s ability to make itself beautiful.

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SHISEIDO Skin Visualizer™ enables the measurement of skin conditions, simply and quickly. With no need to remove makeup and with no actual physical contact. Using two unique cameras, it captures the outer and inner condition of your skin. So you see the skin’s beauty circulation based on measurements at the surface, and also various angle of the skin— an area that is normally invisible.

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SHISEIDO Skin Visualizer™ gives your skin condition a total Ultimate Triangle Score based on your beauty circulation measurements. This triangular graph shows the levels of the three indicators of beautiful skin (radiance, resilience and smoothness) and the balance between them. It allows anyone to monitor their skin condition objectively, regardless of age, gender, skin color or skin type.

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At stores where SHISEIDO Skin Visualizer™ is available, beauty consultants will provide skincare advice that is customized to each individual’s skin condition, based on the visualized beauty circulation. We invite you to try SHISEIDO Skin Visualizer™ for yourself. Discover your own beauty circulation, and you can increase your skin’s vitality and achieve beautiful skin from its very foundations by skin care recommended based on the measurement results.
Take this step, and you’ll be on a path towards obtaining your most ideal skin conditions for a lifetime.

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We will keep posting new information on this site.
Stay tuned.

# LifebloodResearch

Lifeblood Research™ Lab is committed to sharing information
on blood flow science with people.
Please use the hashtag “#LifebloodResearch” when you post your thoughts,
so that we can learn from your feedback.